GW501516 (also known as GW-501,516, GW1516, GSK-516, Cardarine, and on the black market as Endurobol) is a PPARδ receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s, was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases, and was abandoned in 2007 because animal testing showed that the drug caused cancer to develop rapidly in several organs.
In 2007 research was published showing that high doses of GW501516 given to mice dramatically improved their physical performance; the work was widely discussed in popular media, and led to a black market for the drug candidate and to its abuse by athletes as a doping agent. The World Anti-Doping Agency (WADA) developed a test for GW501516 and other related chemicals and added them to the prohibited list in 2009; it has issued additional warnings to athletes that GW501516 is not safe.
PubChem CID 9803963
ChemSpider 7979723 UNII
Cardarine’s Effects on Muscle Fibers
The 2015 study by Wei Chen, Ph.D. and his colleges has also found that dramatic increases in the PPAR gene in slow twitch muscle fibers increases oxygen usage and greatly increases endurance. The enhanced endurance was seen in lab mice with a normal oxygen supply and those with oxygen restrictions which provided significant evidence that GW501516 targets and enhances skeletal muscle endurance and recovery time to a supraphysiological level.
GW-501516 Side Effects
Not to say that there are none, but in the last 20 years no side effects have been seen by anyone studying the drug.
GW501516 has not only been tested in healthy subjects, but also those with simulated “real life” habits (such as drinking alcohol, stimulant narcotics, and the use of tobacco products). It is uncertain if there are long-term ramifications, but no research has been published stating otherwise.
This is what makes Cardarine so incredibly popular and usable over long periods of time. In certain studies, there have even been signs showing the reversal of diabetes, obesity, Dyslipidemia and many other diseases.
In contrast to popular belief, GW501516 doesn’t promote damage to liver cells. The chemical has actually been known to promote healthy liver function and faster healing properties to the skin and muscle tissue. In essence, you will not heal rapidly like Wolverine from the X Men movies, but you will shorten your recovery time from scratches, blisters, and injured muscles by a significant amount.
There have been many forum comments expressing the concerns of GW501516 and it’s relationship to cancer and tumor development. The hypothesis for this controversy stems from GW’s ability to improve Angiogenesis in the body at an extremely high rate and the rate of cancer growth in the colons of lab mice.
This is a common occurrence among endurance athletes and children going through adolescence. Scientists had speculated that if there were tumor cells active in the body, that they would be especially susceptible to angiogenesis and cause the tumor to grow at a much faster rate. Since 2004 many experiments have been done to prove this hypothesis, but so far, all of them have been largely unsuccessful.
Recommendations & Dosing Guidelines for Cardarine
10-20 mg per day is a sufficient dose. It is recommended to start at 10mg per day to take advantage of the host’s sensitivity to the new chemical. 10 mg a day is aimed for endurance, and the higher the dosage the greater the fat loss benefits are going to be
Lab mice should be given dosages 45 minutes- 1 hour before exercise.
GW501516 has been tested for a 2-year study and has found no decreases or stagnation in effects. Most individuals run cycles for 12-14 weeks at a time with a 4-6 week break. This is normally to coincide with a SARM cycle, but there is no evidence showing that GW 501516 needs to be off-cycled after such a short amount of time. GW 501516 was created for LONG TERM usage, so there is no reason why it shouldn’t be used that way.
Half-life is between 16-24 hours and should be taken at 10mg once a day or 10mg once every 10-12 hours if taken at a higher dose.
No PCT is needed, GW is recommended in combination with PCT if highly toxic anabolics have been used.
Highly recommended to use with a ketogenic diet.
Can be used in conjunction with anabolics and stimulants of any kind without adverse reactions.
The research conducted regarding the dosage of Cardarine is quite limited. So we still don’t have a recommended dosage for this compound. However, the average dosage taken by users is 10 ml per day. The half-life of this compound is around 24 hours, so you only need to take it once a day. If you want to split the dose, you can take one in the morning and one in the evening. Cardarine is taken in liquid form only, mostly via a dropper.
It is advised to take your dose an hour before going for any physical activity. Also, some experienced users up their dose to 20 mg per day. However, make sure you don’t exceed this dose. A typical Cardarine cycle lasts from 4 to 6 weeks. Also, go for a proper PCT after completing your cycle to reverse all the health damage.