What is Ostarine?
MK-2866 Ostarine bottleOstarine (MK-2866) is a SARM developed by GTx for the prevention and treatment of muscle wasting. It may eventually be a medical prescription for the prevention of cachexia, atrophy and sarcopenia as well as for Hormone or Testosterone Replacement Therapy.
As a research chemical, Ostarine belongs to a class of chemicals know as SARMS or selective androgen receptor modulators. SARMS create selective anabolic activity at certain androgen receptors. In comparison to testosterone and other anabolic steroids, the advantage of SARMS, is they do not have androgenic activity in non-skeletal muscle tissues. Ostarine is effective in maintaining and increasing lean body mass.
How does it work?
SARMS bind to the androgen receptor and demonstrate osteo (bone) and myo (muscular) anabolic activity.
Androgen receptor activation
Binding and activation of the Androgen receptor alters the expression of genes and increases protein synthesis which builds muscle. In essence, SARMS like ostarine cause muscle growth in the same manner as steroids, however unlike testosterone and other anabolic steroids, SARMS do not produce the growth effect on prostate and other secondary sexual organs.
Ostarine in particular exerts its anabolic effects on muscle tissue almost exclusively. So not only does it represent a new potential treatment option for a wide spectrum of conditions from muscle wasting diseases (from age-related to AIDS or cancer-related), but is also has immense potential for muscle building for bodybuilders, fitness, athletes and an agent to minimize atrophy during recovery periods from serious surgery or similar situations.
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Some of the other benefits include:
Increased lean mass gains
Joint healing abilities
Anabolic (even at doses as low as 3 mg)
Losing Bodyfat (cutting)
Ostarine would primarily fit into a cutting protocol for the maintenance of muscle mass while reducing calories. One of the most disheartening outcomes of cutting is the loss hard earned muscle mass. The drop in metabolic rate and hormone levels (T3, IGF, Testosterone etc) with the lack of calories is a perfect catabolic environment for loss of muscle tissue. As Ostarine has anabolic effects, the dieter can cut calories without having to worry about muscle or strength loss. Ostarine has also shown noticeable nutrient partitioning effects among users, another reason why it can be of great help when cutting.
Lean muscle gains
Ostarine is the most anabolic of any SARMS, making its first and foremost use for wanting to gain lean muscle. The gains in total weight will not be comparable to bulking steroids, however the total gains will almost entirely be lean muscle.
The gains that are made on ostarine are very keepable and users generally see an increase of up to 7 lbs. of lean body mass over and 8 week cycle at 25mg day (diet dependent). The most common dosage is 25 mg for 8 weeks. The side effects that one encounters with steroid use will not be present on cycle.
Generally, with ostarine, the higher the dosage, the more suppression. Although suppression is minimal and is nowhere comparable to suppression that one encounters on steroids, any cycle of ostarine over a 4 weeks period requires a 3 week mini pct. A serm is not required in this pct.
MK-2866, although totally safe, can provide subtle but consistent gains in muscle, size, and strength in your rodent. It’s safe to say you can easily gain 5-10 lbs of muscle over several weeks.
What’s most important is that the gains you receive are lasting and will stay with you for the most part. If your diet and workouts are on point, you will definitely see some amazing results from MK-2866.
MK-2866 uses its anabolic effects on muscle tissue fully so it’s not only a potential cure for muscle wasting ailments but brings incredible benefits to athletes who want to build muscle. It is also an agent to reduce degeneration during recovery times from serious surgery or similar conditions.
*Ostarine has undergone 8 scientific trials by GTx with about 600 subjects plus 3 efficiency studies. A 4-month Phase IIb medical trial including 159 patients have shown a complete boost in total lean muscle mass compared to placebo and the secondary goal of increasing muscle strength.
In terms of bodybuilding, Ostarine users have proven that MK-2866 can help improve lean muscle mass and strength levels.
Muscle Building. This compound does not only help in preventing loss of muscle tissue but also helps you gain lean muscle mass. It works amazingly for you whether you want to lose body fat or gain muscle mass. The best thing about this compound is that it ensures that your gains are actual gains and not water. It does not lead to fat gain or water retention, unlike other steroids.This basically means that the results will be a bit slow but you can be sure that the muscles you gain lean muscles and not just packed water or fat. Water retention can be very frustrating at times, which is why users love this compound.
Burning fat. Ostarine is a very effective weight loss tool. It ensures that you burn more calories than you intake. Losing weight can be very difficult at times and exercise alone can not give you the results that you want to see. So adding this compound in your diet can be of great help. Many users have confirmed that they have witnessed a considerable reduction in their body fat after cycling with this compound.
Other benefits. This compound does not lead to gynecomastia. So you don’t need to worry about developing female-like breasts. Moreover, Ostarine improves recovery time so you can work out more frequently. Lastly, it will be easier for you to maintain your gains because they’re actual lean muscles and not fat or water.
Benefits of the well known SARM Ostarine have been documented in countless studies with effective dosages ranging from 25mg to 50mg per 24-36 hours.
There is no evidence that surpassing the 50mg dosage will provide any increases in benefits.
Even though MK2866 resembles a mild version LGD 4033, it’s duration and tolerability throughout multiple studies have demonstrated safety and effectiveness for up to 6 months (24 weeks).
The best Ostarine dosage would be roughly 20 to 30mg for about 6 weeks. You can choose to extend the cycle if you are making good progress, however that would be completely up to you.
This compound is taken orally in the form of solution or tablets. In tablet form, the recommended dosage is 1-2 tablets per day. Experienced users can increase their dose up to 3 tablets.
The recommended cycle duration is 6-8 weeks and it is reported that the results start becoming visible in the 4th week of use.
Also, when your cycle is completed, make sure to take a 4 week break before starting the next round and take proper post cycle therapy meanwhile in order to recover from all the health damage.
Ostarine shines best when used for gaining lean muscle (bulking) or putting on extra size. The Ostarine dosage for bulking is 20-30 mg for 4-6 weeks. PCT is not necessary. An increase of 6 lbs. of lean, keepable gains can be observed during this period. That is pretty amazing if you think about it, we all know how hard it can be to gain and keep lean muscle.
You can take Ostarine as high as 40 mg for 8 weeks BUT only if you weigh 210 lbs. Suppression is expected in higher doses so PCT after a cycle is a must.
A 15-20 mg dosing protocol for 6-8 weeks is good for cutting with Ostarine without undergoing any side effects or high suppression. However it must be stated that due to the lack of androgenicity, muscle hardness and overall results are not as prominent as with the SARM S-4.
Recomping is where ostarine truly shines. The recomping effect of losing fat and gaining muscle at the same time is what the majority of users are looking for. Trying to achieve this when you are not absolutely new to training is extremely difficult.
Where Ostarine shines for recomping is in its nutrient partitioning benefits. Calories are taken from fat stores and calorie intake is fed to the muscle tissue. In fact many users report that Ostarine consumed at maintenance calories produces weight loss, while still getting increases in strength and muscle mass.
One of the most important factors of recomping is time. As you are trying to achieve multiple objectives, it requires a longer time period to notice good recomp effects so even when running steroids, these would have to be longer run injectable compounds as opposed to the short used liver toxic oral steroids.
Although Ostarine is taken orally, it is not methylated and is not toxic to the liver and does not have a negative effect on ones blood pressure. Therefore it can be run for longer than oral steroids.
The dosing protocol of 20-25mg for 6-8 weeks will give excellent recomp effects.