S4 (Andarine)

1) Product Name:Sarms s4/S4 Andarine

2) Specification:≥99%  

3) Appearance:yellow powder

4) Introduction:   

Andarine (401900-40-1) is an orally active partial agonist for androgen receptors. Andarine 99.5% or Andarine 401900-40-1, Andarine (Sarm S4) 99.5% are the most common form of andarine. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects sarms s-4 andarine
Andarine is able to competitively block binding of dihydrotesarms s-4 andarine stosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH. sarms s-4 andarine

5) Application:

Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy, using the non-steroidal androgen antagonist bicalutamide as a lead compound.

Andarine (S4) was developed by GTX Inc. for the treatment of muscle wasting, osteoporosis and BPH (enlargement of the prostate). It belongs to the class of drugs called SARM’s – selective androgen receptor modulators. Today, it is popularly used and sold as a research chemical, which is used by athletes who seek to get all of the strength benefits and lean muscle gains without the harmful side effects observed with anabolic steroids. Moreover, andarine is also used as part of steroid stacks to improve a cycle without adding more side effects, or aromatization.

S4 (Andarine) or Acetamidoxolutamide, is a SARM (Selective Androgen Receptor Modulator). But the idea for S-4 didn’t start out as many believe.

All SARM’s work by binding to the androgen receptors, which results in anabolic activity. Furthermore, there is more protein synthesized, allowing more muscle to be created. These effects are similar to those seen with anabolic steroids. However, in the case of SARMS, there is no aromatization, liver strain, severe HPTA (hypothalamic pituitary testicular axis) suppression and general side effects.

It wasn’t an attempt to create a safer version of steroids or any of that nonsense people use to sell anabolics.

S-4 started out as a new development for male contraceptives and showed promising results like decreases in spermatogenesis and huge boosts in male libido. For any of you who have had trouble getting your wife pregnant while on sarms…you’re welcome.

However, when researchers began experimenting on mice with S4, they discovered interesting findings of how this first generation SARM affected castrated lab mice.

Not only did Andarine increase the production of muscle mass and calcium for bone density, but was COMPLETELY SELECTIVE in its tissue growth!

As studies continued, many of these research trials resulted in astonishing outcomes creating a benchmark for even more research.

One of the things I like best about S4/andarine is the strength gains. I personally think that the strength gains are comparable to steroids such as anavar or even the prohormone epistane. Retaining your strength while on a cutting cycle is incredibly difficult, but adding andarine to your cutting cycle will ensure that you do not lose those strength gains that you spent so long training to achieve. Typically on a cutting cycle, it is expected to lose strength gains. This is not the case when you are on S4. In fact, I typically gain a good amount of strength even on cutting cycles. I’ve hit numerous PRs while in cutting mode which is no small feat.

Today, we’ll take a closer look at everything we currently know in 2018 about Andarine in this write-up…

How Andarine (S4) Works
To start, let’s describe what a SARM does.

There are three type of chemicals that act on the androgen receptor (AR):

1st is the AR antagonist, which is a chemical that binds to the receptor to prevent it from activating.
2nd is an AR agonist, which binds to the receptor and detaches, then binds again, over and over.
3rd is an AR modulator, or basically a molecule that attaches to an AR and changes its structure to react however it wants.
A SARM such as S-4 is a good example. S-4 attaches to the AR and sticks to it; each time the AR interacts with testosterone, S-4 forces it to produce genes that exclusively benefit muscle and bone growth. In other words, S4 is a form of SARM that attaches to the androgen receptor (AR) the same with regular androgens, the only variation is that S4 generates selective anabolic activity.

As mentioned earlier, SARMS function by tying to the AR resulting to anabolic activity. Due to this fastening and stimulation, more protein is produced which allows muscle building. S4 can trigger muscle development in the same way as steroids, but minus the same unwanted side effects.

S4 is a SARM with utmost androgenic effects and is 33% of the strength of testosterone when attaching to AR.

S-4 also increases the amount of muscle mass produced by desensitizing the AR to the individual’s natural testosterone to influence a stronger effect.

The Key Benefits of S4 (Andarine)
S-4 is by far the most versatile SARM ever created. Not only is it the first SARM approved for a stage 2 research study, but it has also become the most analyzed and investigated SARM so far. After the discovery of its anabolic potential, the primary purpose of S-4 aimed to develop an alternative treatment to age-related muscle wasting, osteoporosis, and similar symptoms of hypogonadism, or end-stage renal disease.

Aside from preserving lean body mass, S4 can also help improve it.

From a stage 1 study, S-4 has provided evidence of a 3.3 lbs increase in less than 90 days with no increases exercise or change in daily diet. An unintended side effect (or benefit if you will) is the decrease in body fat [Chen et al., 2005; Gao et al., 2005; Kearbey et al., 2007]. Decreases in body fat are dependent on the person’s genetics, but it will definitely have strong effects on the body’s ability to oxidize fatty tissue. S-4 was found to not only have a great affinity (potency in binding to androgen receptors), while also presenting greater anabolic effects than some traditional steroids

Aside from its muscle building advantages, S4 won’t cause liver damage, can prevent gynecomastia (enlarged breasts in men) and can help boost your overall health.

Here are some of the other benefits of Andarine that are worth noting:

Very minimal growth on secondary sexual organs such as the prostate.
The LDL/ HDL ratio is not affected which makes it a low cardiovascular risk.
0% chance of aromatization, male breast lactation, or rise in any other female characteristic during the post cycle recovery. [Kearbey et al., 2007]
Testosterone is not diminished in any capacity during the post cycle recovery.
Very exclusive in tissue selection and growth which means it will not cause heart enlargement or damage to neighboring organs.
SARMs do NOT require the utilization or devouring of liver enzymes to activate their anabolic effects. This eliminates any risk of hepatotoxicity or hepatitis.
Although SARMs such as S-4 are not as powerful as comparable steroids such as Winstrol, they do not require the extensive post cycle therapy and can be cycled back to back throughout the year. Over the course of a year, obtaining the same results is very possible.
SARMs is very female friendly and does not cause excessive masculine features such enlarged sexual characteristics.
S-4 has overall presented larger increases in muscle mass than DHT.
Luckily, andarine does not have a lot of side effects. There are a few you should know about, though. It is possible to experience mild shut down on S4. This is only an issue if you run S4 for much longer than recommended. The good news is that even if you do experience mild suppression, your body will bounce back naturally. You can speed up the recovery process by doing a post cycle therapy supplement after your cycle.
Full Muscle Regeneration & Lean Body Mass
Once more, an early study done on S-4 provided proof of full muscle regeneration in volunteers with degenerative disorders without the use of exercise and the minimum dosage of 3mg/kg/day. Changes can be seen anywhere from 1-2 weeks. This was the very first study classified S-4 as CLINICALLY SIGNIFICANT by improving skeletal muscle strength, lean body mass, and a reduction in body fat [Chen et al., 2005; Gao et al., 2005; Kearbey et al., 2007]. Unfortunately, there are always some side effects that arise when using Because S-4 is a ligand by definition, the side effects will never be permanent even at supraphysiological dosages and can be easily avoided through proper dosing.

One study in particular compared S-4 to DHT (a common anabolic steroid); the results have shown that S-4 exceeded DHT in producing lean muscle mass over the course of 120 days with only 3mg per day. Another study identified that S-4 is completely absorbed even at very low doses.

Here are some more general guidelines depending on goals:

Most people have opted to split their 50mg to 75mg doses into 3 separate doses (one with each meal), 5 days per week for no more than 12 to 16 weeks. This has become somewhat of a dogma but there are now studies proving that it is any more effective than one solid dose once a day [Chen et al., 2005a; Gao et al., 2004; Gao et al., 2005; Kearbey et al., 2007; Kearbey et al., 2004].
Once again, as mentioned above, S-4 does have a point of diminishing returns. This means usage of S-4 passed 75mg or usage of S-4 for more than 16 weeks will not result in any added muscle mass. There will not be an increase in side effects either, but you will be running the risk of AR desensitization and inevitably wasting your product.
Dosing with S-4 for less than 6-8 weeks is not recommended and will not allow the researcher to witness the full benefits of the product.
The recommended dose for cutting is 50 mg for 6-8 weeks. You should use it every day then take 2 days off for the duration. Taking S4 daily for the length of the cycle can lead to changes in eyesight.