SR9009 is one of a pair of compounds developed at TSRI by Burris and his team. The drug binds to Rev-erbα, a natural protein in the body that influences lipid and glucose metabolism in the liver, inflammatory responses, and fat-storing cells. By binding to Rev-erbα, SR9009 can kickstart metabolism with another pleasant side-effect: increased muscle strength.
In spite of being associated with SARMS, Stenabolic (SR9009) is in fact a Rev-ErbA ligand. It means SR binds to this protein and makes it more active. As a result, the user will experience a lot of positive effects, such as increased fat loss, enhanced endurance, and many other health benefits. Interestingly, it is one of the newest advances in pharmacology, but it is already getting more and more popularity among athletes all over the world. Therefore, in this article we will discuss what SR9009 is, how it works, and all the benefits it can offer to the user.
History of SR-9009
SR9009 was first developed by Professor Thomas Burris from The Scripps Research Institute. Initial findings were published in the journal Nature Medicine in 2012, with studies showing that Stenabolic significantly increases exercise endurance in animal models.
The compound affects the core biological clock, synchronizing the body’s circadian rhythm with the 24-hour cycle of day and night.
How SR-9009 Works
The compound SR9009 works by binding to one of the body’s naturally occurring molecules, called Rev-Erbα. This molecule influences lipid and glucose metabolism in the liver, the production of fat-storing cells, and the response of macrophages (cells that remove dead or dying cells) during inflammation.
The study showed that mice lacking Rev-Erbα had decreased muscle metabolic activity and running capacity. However, Burris’ group demonstrated that activation of Rev-Erbα using Stenabolic led to increased metabolic activity in skeletal muscle in both culture and mice. The difference was a 50% increase in running capacity for mice treated with SR9009 – even when exercise was restricted.
Professor Burris explained that the study resulted in animals developing muscles just like an athlete who has been training, even when they haven’t. He believes that Rev-Erbα affects muscle cells through the creation of new mitochondria, and the removal of defective mitochondria via macrophages.
Basically, SR-9009 is one of the strongest endurance boosters out there. It is often compared to GW-5051516 (Cardarine) because the benefits are comparable.
There are 7 primary benefits of SR9009 that have been observed in both initial studies and user-reported reviews.
SR9009 increases weight loss
Stenabolic shows great promise in increasing weight loss, even without exercise – which is why it’s being touted as “exercise in a bottle”.
In initial studies, researchers chose mice with low skeletal muscle and metabolism to treat with SR9009. Over a 30-day study, the muscle and metabolic rate of the mice increased, even when they weren’t allowed to exercise.
Increased mitochondria activity was noted in muscle, as well as an increase in macrophages – cells that remove dying or dead cells – enhancing the energy output of the animal’s muscles to create athletic, oxidative muscle without any actual exercise.
Due to this increase in muscle activity, SR9009 helped the body burn calories instead of turning them into fat, effectively allowing an increase in weight loss.
SR9009 increases stamina and endurance
Additional to muscle conditioning, initial studies showed that once the mice that were treated with Stenabolic for 30 days were allowed to exercise, they showed a 50% increase in endurance – running longer and covering more distance than controls.
This may be due to an increase in the glucose oxidation in skeletal muscle, allowing the body to go faster for longer with a higher level of strength and stamina.
According to Burris:
“The animals actually get muscles like an athlete who has been training. The pattern of gene expression after treatment with SR9009 is that of an oxidative-type muscle— again, just like an athlete.”
SR9009 may lower blood cholesterol
Mice treated with SR9009 for 7-10 days showed reduced blood levels of triglycerides and total cholesterol.
Another study suggested that targeting Rev-Erbα may be an effective method for suppressing LDL cholesterol levels using SR9009. Over an 8-week period, genetically modified mice with a similar fat profile to humans were treated with SR9009, resulting in a significant decrease in total cholesterol, triglycerides, and LDL cholesterol.
SR9009 indicates a decrease in inflammation
Stimulation of Rev-Erbα activity by SR9009 was shown to greatly diminish ventilator-induced lung edema and inflammatory cells in rats.
The study suggests that the circadian rhythm affects the immune response, which may exacerbate inflammation. As Rev-Erbα plays a role in regulating the circadian rhythm, SR9009 may help reduce inflammation by activating Rev-Erbα.
SR9009 may increase wakefulness
Due to its ability to activate Rev-Erbα, Stenabolic can affect the wakefulness of mice. As it affects the circadian rhythm, when SR9009 was injected into mice during periods they usually sleep, they were kept awake longer and had less REM sleep.
However, when the mice were injected with SR9009 during their normal awake hours, there was no perceptible change in their behavior.
This suggests that Stenabolic may be useful for sleep-related disorders such as narcolepsy or shift workers.
SR9009 may reduce heart disease
Studies show that both normal and genetically modified older mice had improved heart function when injected with SR9009. Mice with surgically-induced heart growth (hypertrophy) showed a reduction in heart size and weight without affecting their blood pressure after two weeks of treatment with SR9009.
SR9009 may effectively reduce anxiety
Mice injected with SR9009 twice per day for 3 to 10 days showed decreased anxiety-like behavior. Interestingly, it has been suggested that SR9009 was as effective as a benzodiazepine, even though it shows potential to increase stamina and endurance of athletes.