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Can DMF be heated?
Hot solutions of sodium tetrahydroborate (15.7% wt) in DMF will undergo a violent runaway thermal decomposition, the solid residue attaining a temperature of 310 deg C. The induction period depends on temperature and is 45 hr at 62 deg C and 45 min at 90 deg C.
DMF dissolves amino acids and coupling reagents and does not react with piperidine, but this reagent can jeopardize peptide synthesis by decomposition into formaldehyde (HCHO) and dimethylamine (HNMe2).